汀臭崽儿
business It's not your business 这不关你的事issue we are having an issue. 我们现在有事matter what's the matter? 发生什么事了?

~*诗情画意*~
应该是thing。楼上说的不对,business是商业,issue是问题,只有matter差不多,是事件的意思。所以总的来说“thing”才是正确的,这个词是可数名词,也就是说如果很多件事可以在thing后面加个s,变成“things”。
念念花语
trifle 小事,琐事[C]A mere trifle brought about a quarrel between the brothers. 一点儿小事引起了兄弟间一场争吵。另外表示事件常用词语有:a. event通常指具有很大影响、意义大的事件或运动会的比赛项目。如: Can you remember the events which happened in the 1960s? The Autumn Uprising is a great event in China's histroy. There are 300 different events in the Olympic Games.b. matter 意思为“毛病”、“问题”,通常指“要注意的事情”。如: What's the matter with you ? It's a different matter.c. affair 指已经发生或必须去做的事情,通常用复数形式指“事务”“事 态”如:the world affairs, foreign affairs.d.incident则指不太重大但是引人注意的小事件,又指有预谋的政治事件,如the July 7th Incident of 1937(1937年的“七七事变”); 希望帮到你