Abstract Objective: To explore the Leonurus anti-inflammatory and analgesic pharmacological Methods: xylene-induced mouse ear swelling and carrageenan-induced rat paw swelling in mice granuloma Leonurus experimental observation of the anti-inflammatory effect, using heat stimulation and chemical stimulation induced pain, observation of its analgesic Results: Motherwort right ear swelling in mice, rat paw edema and cotton ball granuloma of mice were significantly inhibited, can significantly improve the hot-plate test in mice in the pain threshold, reduce the number of Conclusion: Motherwort has significant anti-inflammatory and analgesic pharmacological